Letter from Francis Crick to Aaron Klug

Letter from Francis Crick to Aaron Klug

Contributor(s):
The Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
Klug, Aaron
Crick, Francis, 1916-2004
Publication:
Produced: 4 October 1977
Language(s):
English
Format:
Text
Subject(s):
DNA
Chromosomes
Genre(s):
Archival Materials
Letters (correspondence)
Abstract:
Crick here evaluated research results by two of his coauthors, Leth Bak and Jesper Zeuthen, used in an article the three wrote on the structure and folding of DNA and its associated proteins in human chromosomes during cell division (mitosis). In their article they postulated that chromatids, the one-half of a chromosome that splits off from the other half during cell division, were organized in a hierarchy of helices: the chromatid is a folded and coiled super-solenoid (a long, regular, hollow cylindrical structure), also called the unit fiber, which in turn is formed by a coiled solenoid of smaller diameter, which in turn is formed by coiling the string of nucleosomes, bead-like complexes of DNA and protein.. See Leth Bak, Jesper Zeuthen, and Crick, "Higher-Order Structure of Human Mitotic Chromosomes," Proceedings of the National Academy of Sciences, vol. 74 (April 1977), pp. 1595-99.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
2 pages
NLM Unique ID:
101584582X244 (See in Profiles in Science)
Profiles in Science ID:
SCBBQW
Permanent Link:
http://resource.nlm.nih.gov/101584582X244
Archival Collection:
The Francis Crick Papers (Profiles in Science)