Letter from Francis Crick to Aaron Klug

Letter from Francis Crick to Aaron Klug

Contributor(s):
The Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
Klug, Aaron
Crick, Francis, 1916-2004
Publication:
Produced: 20 June 1977
Language(s):
English
Format:
Text
Subject(s):
DNA
Nucleosomes
Genre(s):
Archival Materials
Letters (correspondence)
Abstract:
Crick here commented further on the draft of a paper by Klug on the spatial arrangement of DNA and histones (proteins associated with DNA) in nucleosomes. Particularly, Crick debated the dimensions of the DNA helix in nucleosomes and how the DNA helix was itself coiled in a nucleosome (forming a coiled coil, or superhelix). Nucleosomes have since been determined to consist of eight histone molecules wrapped by a DNA segment of about 150 base pairs in length. Under the electron microscope nucleosomes, which are linked to each other by DNA sequences about fifty base pairs in length, appear as bead-like bodies on a string.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
2 pages
NLM Unique ID:
101584582X232 (See in Profiles in Science)
Profiles in Science ID:
SCBBQH
Permanent Link:
http://resource.nlm.nih.gov/101584582X232
Archival Collection:
The Francis Crick Papers (Profiles in Science)