Mutagenesis by Acridines in Bacteriophage T4

Mutagenesis by Acridines in Bacteriophage T4

Contributor(s):
The Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
Crick, Francis, 1916-2004
Publication:
Produced: [ca. 1961]
Language(s):
English
Format:
Text
Subject(s):
Genetic Code
Genre(s):
Archival Materials
Lecture notes
Abstract:
In this lecture Crick provided an account of genetic experiments conducted with Leslie Barnett, Sydney Brenner, and Richard Watts-Tobin in 1961. In these experiments they used acridine mutants of viral DNA (mutants produced by chemicals of the acridine type, such as proflavin, which trigger additions to or deletions from the base sequence) in order to demonstrate that the genetic code was a three-letter code. They published their findings in a seminal article in Nature in December 1961, entitled "General Nature of the Genetic Code for Proteins."
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
3 pages
NLM Unique ID:
101584582X23 (See in Profiles in Science)
Profiles in Science ID:
SCBBCP
Permanent Link:
http://resource.nlm.nih.gov/101584582X23
Archival Collection:
The Francis Crick Papers (Profiles in Science)