Letter from Sewell Champe to Francis Crick

Letter from Sewell Champe to Francis Crick

Contributor(s):
The Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
Crick, Francis, 1916-2004
Champe, Sewell
Publication:
Produced: 9 October 1966
Language(s):
English
Format:
Text
Subject(s):
Genetic Code
Genre(s):
Archival Materials
Letters (correspondence)
Abstract:
Champe here revealed that he had resumed research with the rII mutants of the bacterial viruses T2 (phage), which had been used since the early 1950s in genetic mapping experiments. These experiments were designed to break up genes into their component parts, eventually down to the level of individual bases--at a time when biochemical means of sequencing the bases of DNA were several years in the future.. One goal of researchers had been to map changes in the mutant strain rII to changes in the amino acid sequence of the protein for which it coded. (Upon infection viral nucleoprotein, an assembly of nucleic acid and protein, enters the bacterial cell, where it induces the synthesis of more viral nucleoprotein, which is released when the cell ruptures.) However, the protein for which rII coded had never been found. Champ and his co-workers resumed the search in the fall of 1966.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
2 pages
NLM Unique ID:
101584582X210 (See in Profiles in Science)
Profiles in Science ID:
SCBBPF
Permanent Link:
http://resource.nlm.nih.gov/101584582X210
Archival Collection:
The Francis Crick Papers (Profiles in Science)