Letter from H. Gobind Khorana to Francis Crick

Letter from H. Gobind Khorana to Francis Crick

Contributor(s):
The Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
Crick, Francis, 1916-2004
Khorana, Har Gobind, 1922-2011
Publication:
Produced: 22 May 1974
Language(s):
English
Format:
Text
Subject(s):
Genetic Code
RNA
Genre(s):
Archival Materials
Letters (correspondence)
Diagrams
Abstract:
In his letter Khorana reported progress in his ongoing effort to synthesize in the laboratory a gene that codes for the transfer RNA of the amino acid tyrosine. In particular, he described work on the synthesis of the promoter sequence, a segment of DNA, usually located before a gene coding region in the base sequence, which acts as a controlling element in the expression of that gene, for example by regulating the beginning and the speed of transcription from DNA to RNA. Khorana also discussed the terminator sequence, which signals the end of the polypeptide chain in protein synthesis. He detailed the structure of the promoter and terminator sequences in schematic drawings attached to his letter.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
6 pages
NLM Unique ID:
101584582X179 (See in Profiles in Science)
Profiles in Science ID:
SCBBMR
Permanent Link:
http://resource.nlm.nih.gov/101584582X179
Archival Collection:
The Francis Crick Papers (Profiles in Science)