In his letter Hamilton speculated how recent findings in chemistry and biochemistry related to Crick's concept of directed panspermia, the idea that life on earth was deliberately seeded by an extraterrestrial civilization. Crick speculated that life on earth evolved from a single source--perhaps supplied externally--because the genetic code is universal to all organisms. Hamilton asked what the implications of a universal code were for the future course of evolution, if the genome was subjected to man-made mutation-inducing agents.
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