The Enzymatic Deamination of Amphetamine (Benzedrine)

The Enzymatic Deamination of Amphetamine (Benzedrine)

Contributor(s):
Axelrod, Julius, 1912-2004
Journal of Biological Chemistry
Publication:
American Society for Biochemistry and Molecular Biology, June 1955
Language(s):
English
Format:
Text
Subject(s):
Microsomes
Amphetamine
Deamination
Genre(s):
Archival Materials
Articles
Abstract:
Part of long series of research articles on the role played in the body by sympathetic amines, in this paper, Axelrod compared the transformation of amphetamine in rabbits to rats, dogs, and guinea pigs. The subject of the article originated in Axelrod's curiosity as to why when amphetamine was administered to rabbits it disappeared entirely. Axelrod found in this article that one or several enzymes in a rabbit's liver deaminated amphetamine, leading to the formation of phenylacetone and ammonia. He also determined that ephedrine was similarly demethylated to norephedrine and formaldehyde by the microsomal drug metabolizing enzymes.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
12 pages
NLM Unique ID:
101584577X9 (See in Profiles in Science)
Profiles in Science ID:
HHAAAI
Permanent Link:
http://resource.nlm.nih.gov/101584577X9
Archival Collection:
The Julius Axelrod Papers (Profiles in Science)