Studies on Sympathomimetic Amines. II. The Biotransformation and Physiological Disposition of D-Amphetamine, D-P-Hydroxyamphetamine and D-Methamphetamine

Studies on Sympathomimetic Amines. II. The Biotransformation and Physiological Disposition of D-Amphetamine, D-P-Hydroxyamphetamine and D-Methamphetamine

Contributor(s):
Journal of Pharmacology and Experimental Therapeutics
Axelrod, Julius, 1912-2004
Publication:
American Society for Pharmacology and Experimental Therapeutics, March 1954
Language(s):
English
Format:
Text
Subject(s):
Biotransformation
Sympathomimetics
Metabolism
Genre(s):
Archival Materials
Articles
Abstract:
In this second in a series of papers by Axelrod on the role played in the body by sympathetic amines, a broad class of chemicals that mimic the actions of the sympathetic nervous system and have an amine basic structure, Axelrod found that the fate and physiological disposition of compounds of amphetamine in several species of animals was metabolized by a number of biochemical processes, including hydroxylation, demethylation, deamination, and conjugation. Axelrod again determined that various species showed considerable variations in the ways in which their bodies transformed these drugs.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
13 pages
NLM Unique ID:
101584577X8 (See in Profiles in Science)
Profiles in Science ID:
HHAAAH
Permanent Link:
http://resource.nlm.nih.gov/101584577X8
Archival Collection:
The Julius Axelrod Papers (Profiles in Science)