Studies on Sympathomimetic Amines. I. The Biotransformation and Physiological Disposition of l-Ephedrine and l-Norephedrine

Studies on Sympathomimetic Amines. I. The Biotransformation and Physiological Disposition of l-Ephedrine and l-Norephedrine

Contributor(s):
Journal of Pharmacology and Experimental Therapeutics
Axelrod, Julius, 1912-2004
Publication:
American Society for Pharmacology and Experimental Therapeutics, September 1953
Language(s):
English
Format:
Text
Subject(s):
Biotransformation
Sympathomimetics
Genre(s):
Archival Materials
Articles
Abstract:
This article was the first in a series of papers by Axelrod on the role played in the body by sympathetic amines, a broad class of chemicals that mimic the actions of the sympathetic nervous system and have an amine basic structure. Through a variety of tests on several animals, Axelrod found two primary processes, demethylation and hydroxylation, that metabolically transformed ephedrine. He also noted that various animal species showed considerable differences in the relative importance of the two metabolic routes.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
12 pages
NLM Unique ID:
101584577X7 (See in Profiles in Science)
Profiles in Science ID:
HHAAAG
Permanent Link:
http://resource.nlm.nih.gov/101584577X7
Archival Collection:
The Julius Axelrod Papers (Profiles in Science)