The Distribution and Metabolism of Lysergic Acid Diethylamide

The Distribution and Metabolism of Lysergic Acid Diethylamide

Contributor(s):
Axelrod, Julius, 1912-2004
Brady, Roscoe O.
Annals of the New York Academy of Sciences
Evarts, Edward V.
Witkop, Bernhard, 1917-
Publication:
New York Academy of Sciences, 14 March 1957
Language(s):
English
Format:
Text
Subject(s):
Microsomes
Lysergic Acid Diethylamide
Metabolism
Genre(s):
Archival Materials
Articles
Abstract:
Late in the 1950s, Axelrod became interested in the distribution, excretion, metabolization and rate of "biotransformation" of lysergic acid diethylamide (LSD) by the body. In this first of several articles on the narcotic drug, he detailed the subcellular processes involved in the transformation of LSD, determined the order of concentrations of the drug in various tissues, determined that it was almost completely metabolized by the body, and found that their were considerable differences between various animal species in the rate of biotransformation of LSD.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
10 pages
NLM Unique ID:
101584577X11 (See in Profiles in Science)
Profiles in Science ID:
HHAAAK
Permanent Link:
http://resource.nlm.nih.gov/101584577X11
Archival Collection:
The Julius Axelrod Papers (Profiles in Science)