An Immunologic Approach to the Conformational Equilibria of Polypeptides

An Immunologic Approach to the Conformational Equilibria of Polypeptides

Contributor(s):
Anfinsen, Christian B. (Christian Boehmer), 1916-1995
Sachs, David H. (David Howard), 1942-
Schechter, Alan N.
Proceedings of the National Academy of Sciences of the United States of America
Eastlake, Ann
Publication:
National Academy Press (U.S.), December 1972
Language(s):
English
Format:
Text
Subject(s):
Antigen-Antibody Reactions
Protein Conformation
Antibody Specificity
Epitopes
Genre(s):
Archival Materials
Articles
Abstract:
Certain antibodies are particularly well-suited for the study of the conformational equilibria of polypeptide fragments of nuclease in solution. Here, Anfinsen, Schechter, Sachs, and Eastlake hypothesized that such fragments actually existed in solution in conformational equilibrium, components of which were sufficiently similar to the native conformation that antibodies directed to the native molecule could bind. They were able to validate this hypothesis by using synthetic polypeptide fragments, which were already known to induce folding of complimentary fragments.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
5 pages
NLM Unique ID:
101584571X176 (See in Profiles in Science)
Profiles in Science ID:
KKBBLL
Permanent Link:
http://resource.nlm.nih.gov/101584571X176
Archival Collection:
The Christian B. Anfinsen Papers (Profiles in Science)