Some Relationships of Structure to Function in Ribonuclease

Some Relationships of Structure to Function in Ribonuclease

Contributor(s):
Anfinsen, Christian B. (Christian Boehmer), 1916-1995
Annals of the New York Academy of Sciences
White, F. H., Jr
Publication:
New York Academy of Sciences, 4 September 1959
Language(s):
English
Format:
Text
Subject(s):
Ribonucleases
Oxidation-Reduction
Protein Conformation
Disulfides
Genre(s):
Archival Materials
Articles
Abstract:
This study by White and Anfinsen on the renaturation of fully denatured ribonuclease, or RNase, required subsequent supporting investigations to establish what came to be called the "thermodynamic hypothesis." Here they reported that RNase activity depended upon a variety of structural features, but noted that it could be inferred from the results of their experimentation that only a small part of the enzyme molecule, what they termed the "active center," was necessary for catalyst.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
9 pages
NLM Unique ID:
101584571X166 (See in Profiles in Science)
Profiles in Science ID:
KKBBKY
Permanent Link:
http://resource.nlm.nih.gov/101584571X166
Archival Collection:
The Christian B. Anfinsen Papers (Profiles in Science)