Studies on the Structural Basis of Ribonuclease Activity

Studies on the Structural Basis of Ribonuclease Activity

Contributor(s):
Biochimica et Biophysica Acta
Anfinsen, Christian B. (Christian Boehmer), 1916-1995
Schellman, John
Hvidt, Aase
Linderstrøm-Lang, Kaj, 1896-
Harrington, William F.
Ottensen, Martin
Publication:
Amsterdam Elsevier, 1955
Language(s):
English
Format:
Text
Genre(s):
Archival Materials
Articles
Abstract:
This brief note was the product of Anfinsen's one-year postdoctoral fellowship from the Rockefeller Foundation at the Carlsberg Laboratory in Copenhagen. It was Anfinsen's second tour at the laboratory; his first in 1939-1940 was cut short due the outbreak of World War II. Working with the Danish biochemist Kaj Linderstrom-Lang and others, Anfinsen conducted an in-depth physical analysis of the structure of ribonuclease, or Rnase. The group suggested that only a relatively small part of the Rnase molecule, the "active center," is directly involved in catalytic activity, and therefore an ordered secondary structure in a protein was unnecessary for its properties as a catalyst. This conclusion was largely disproven by Anfinsen's subsequent research into amino acid sequencing and protein folding in the 1960s.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
2 pages
NLM Unique ID:
101584571X164 (See in Profiles in Science)
Profiles in Science ID:
KKBBKW
Permanent Link:
http://resource.nlm.nih.gov/101584571X164
Archival Collection:
The Christian B. Anfinsen Papers (Profiles in Science)