Partial Purification of Human Interferon by Affinity Chromatography

Partial Purification of Human Interferon by Affinity Chromatography

Contributor(s):
Gurari-Rotman, D.
Bose, S.
Anfinsen, Christian B. (Christian Boehmer), 1916-1995
Corley, Lila
Proceedings of the National Academy of Sciences of the United States of America
Publication:
National Academy Press (U.S.), August 1974
Language(s):
English
Format:
Text
Subject(s):
Interferons
Chromatography, Affinity
Methods
Genre(s):
Archival Materials
Articles
Abstract:
In this article, Anfinsen, et al, reported the use of affinity chromatography to purify human leukocyte and fibroblast interferons. By using affinity chromatography, they achieved a significant degree of purification of these interferons, but due to an insufficient supply of starting material, a homogeneous preparation of neither interferon was obtained. Although this study was only partially successful, until this point, efforts to purify interferon to homogeneity, which had tremendous antiviral implications, had resulted mostly in frustration. Only later would true purification be achieved.
Copyright:
This item may be under copyright protection; contact the copyright owner for permission before re-use.
Extent:
4 pages
NLM Unique ID:
101584571X154 (See in Profiles in Science)
Profiles in Science ID:
KKBBKK
Permanent Link:
http://resource.nlm.nih.gov/101584571X154
Archival Collection:
The Christian B. Anfinsen Papers (Profiles in Science)