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Icodextrin in peritoneal dialysis solution may cause falsely high blood glucose readings
Icodextrin in peritoneal dialysis solution may cause falsely high blood glucose readings
Falsely elevated blood glucose level readings can lead to incorrect treatment and, subsequently, serious patient harm or death. Blood containing certain saccharides can falsely elevate the results obtained from point-of-care (POC) glucose meters using the glucose dehydrogenase pyrroloquinolinequinone (GDH-PQQ) enzyme/indicator test method. At-risk patients include peritoneal dialysis patients receiving dialysis solutions containing icodextrin, patients receiving certain types of immunoglobulin therapy, or patients receiving other drugs containing maltose, galactose, or xylose. GDH-PQQ meters cannot distinguish between maltose, galactose, or xylose contained in blood. Mitigation strategies to help facilities reduce or eliminate falsely elevated readings include educating staff and at-risk patients about the problem and becoming familiar with the enzymatic test methods used by POC glucose meters; labeling affected POC meters and contraindicating their use for patients receiving solutions containing icodextrin, maltose, galactose, or xylose; and instructing staff and at-risk patients to use POC meters not based on the GDH-PQQ method.
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