Icodextrin in peritoneal dialysis solution may cause falsely high blood glucose readings

Icodextrin in peritoneal dialysis solution may cause falsely high blood glucose readings

Collection:
Health Policy and Services Research
Series Title(s):
Pennsylvania patient safety advisory
Contributor(s):
Pennsylvania. Patient Safety Authority.
ECRI (Organization)
Institute for Safe Medication Practices.
Publication:
[Harrisburg, Pa.] : Pennsylvania Patient Safety Authority, c2008
Language(s):
English
Format:
Text
Subject(s):
Blood Glucose -- analysis
Blood Glucose Self-Monitoring -- instrumentation
False Positive Reactions
Hemodialysis Solutions
Point-of-Care Systems
Pennsylvania
United States
Genre(s):
Technical Report
Abstract:
Falsely elevated blood glucose level readings can lead to incorrect treatment and, subsequently, serious patient harm or death. Blood containing certain saccharides can falsely elevate the results obtained from point-of-care (POC) glucose meters using the glucose dehydrogenase pyrroloquinolinequinone (GDH-PQQ) enzyme/indicator test method. At-risk patients include peritoneal dialysis patients receiving dialysis solutions containing icodextrin, patients receiving certain types of immunoglobulin therapy, or patients receiving other drugs containing maltose, galactose, or xylose. GDH-PQQ meters cannot distinguish between maltose, galactose, or xylose contained in blood. Mitigation strategies to help facilities reduce or eliminate falsely elevated readings include educating staff and at-risk patients about the problem and becoming familiar with the enzymatic test methods used by POC glucose meters; labeling affected POC meters and contraindicating their use for patients receiving solutions containing icodextrin, maltose, galactose, or xylose; and instructing staff and at-risk patients to use POC meters not based on the GDH-PQQ method.
Copyright:
Reproduced with permission of the copyright holder. Further use of the material is subject to CC BY-NC-DC license. (More information)
NLM Unique ID:
101569760 (See catalog record)
Permanent Link:
http://resource.nlm.nih.gov/101569760