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			<p begin="00:00:02.300" end="00:00:10,666" style="1">[This film is from The Psychological Cinema Register of The Pennsylvania State College] </p>
			<p begin="00:00:10.666" end="00:00:19,566" style="1">[Prefrontal Lobotomy in the Treatment of Mental Disorders] </p>
			<p begin="00:00:19.566" end="00:00:28,766" style="1">[By Walter Freeman and James W. Watts] </p>
			<p begin="00:00:28.766" end="00:00:33,999" style="1">[Photography by Guilo Photographers] </p>
			<p begin="00:00:34.000" end="00:00:39,433" style="1">[From The Department of Neurology, George Washington University]</p>
			<p begin="00:00:39.433" end="00:00:58,233" style="1">[..............................................................................]</p>
			<p begin="00:00:58.233" end="00:01:02,133" style="1">[Narrator:] A review of the landmarks on the skull and the more significant structures  </p>
			<p begin="00:01:02.133" end="00:01:10,299" style="1">in the frontal lobe will give one a clearer impression of the nature of the operation. </p>
			<p begin="00:01:10.300" end="00:01:21,000" style="1">On the prepared skull, at a 0.13 centimeters behind the glabella, the coronal suture is outlined. </p>
			<p begin="00:01:21.000" end="00:01:31,566" style="1">Six centimeters above the zygoma in the coronal suture, the opening is made. </p>
			<p begin="00:01:31.566" end="00:01:42,466" style="1">This corresponds to a point close to the sphenoidal ridge on the interior of the skull. </p>
			<p begin="00:01:42.466" end="00:01:50,966" style="1">The coronal suture on the inside of the skull is observed. </p>
			<p begin="00:01:50.966" end="00:02:03,799" style="1">Note again the sphenoidal ridge behind which the operator must not penetrate for fear of lacerating arteries. </p>
			<p begin="00:02:03.800" end="00:02:11,233" style="1">Turning now to the brain, the frontal lobe is bounded by the Sylvian fissure and the Rolandic fissure. </p>
			<p begin="00:02:11.233" end="00:02:15,799" style="1">The point of entrance of the knife is shown. </p>
			<p begin="00:02:15.800" end="00:02:22,133" style="1">Here is the Sylvian fissure with its large vessels. </p>
			<p begin="00:02:22.133" end="00:02:33,566" style="1">On the mesial aspect of the hemisphere, the genu of the corpus callosum lies here. </p>
			<p begin="00:02:33.566" end="00:02:42,599" style="1">Sectioning the brain in approximately the plane of the coronal suture allows us to expose certain vital points. </p>
			<p begin="00:02:42.600" end="00:02:48,000" style="1">Observe first the corpus callosum and the association pathways. </p>
			<p begin="00:02:48.000" end="00:02:59,233" style="1">Next, the fascicular singuli and the anterior limb of the internal capsule. </p>
			<p begin="00:02:59.233" end="00:03:04,399" style="1">After dissection of the brain, these structures are more clearly seen. </p>
			<p begin="00:03:04.400" end="00:03:15,533" style="1">The fascicular singuli skirts the corpus callosum, and runs down into the temporal lobe. </p>
			<p begin="00:03:15.533" end="00:03:24,099" style="1">The plane of a lobotomy incision lies just anterior to the head of the caudate nucleus. </p>
			<p begin="00:03:24.100" end="00:03:31,766" style="1">When the head of the caudate nucleus is removed, the fibers radiating forward from the thalamus are seen. </p>
			<p begin="00:03:31.766" end="00:03:37,199" style="1">Note the thalamus with its radiation into the temporal and the occipital regions, </p>
			<p begin="00:03:37.200" end="00:03:44,133" style="1">and its anterior radiation into the frontal lobe. </p>
			<p begin="00:03:44.133" end="00:04:28,399" style="1">[.....................................................................................]</p>
			<p begin="00:04:28.400" end="00:04:34,800" style="1">[Narrator:] The patient is lying on the table with his head shaved back as far as the vertex. </p>
			<p begin="00:04:34.800" end="00:04:38,800" style="1">The first mark is made three centimeters behind the lateral rim of the orbit, </p>
			<p begin="00:04:38.800" end="00:04:58,466" style="1">and then a cross-mark is made six centimeters above the zygoma. </p>
			<p begin="00:04:58.466" end="00:05:08,132" style="1">Another mark is made in the midline, 13 centimeters from the glabella. </p>
			<p begin="00:05:08.133" end="00:05:21,933" style="1">These points are joined by a line leading over the vertex, following as accurately as possible, the coronal suture. </p>
			<p begin="00:05:21.933" end="00:05:26,033" style="1">Midline is similarly indicated. </p>
			<p begin="00:05:26.033" end="00:05:53,833" style="1">Operations can be performed under local anesthesia if the patient is sufficiently cooperative. </p>
			<p begin="00:05:53.833" end="00:06:06,699" style="1">An incision through the scalp along the indicated line exposes the coronal suture. </p>
			<p begin="00:06:06.700" end="00:06:16,700" style="1">The periosteum is scraped off and markings are made with a chisel. </p>
			<p begin="00:06:16.700" end="00:06:27,833" style="1">The wound edges are then retracted with a self-retaining mastoid retractor. </p>
			<p begin="00:06:27.833" end="00:06:47,333" style="1">A bore hole is placed in the coronal suture by means of successive drills. </p>
			<p begin="00:06:47.333" end="00:06:59,933" style="1">The opening is then enlarged in the line of the coronal suture by a rongeur to give greater play for the knife. </p>
			<p begin="00:06:59.933" end="00:07:06,733" style="1">The dura is opened, and the cortex is punctured in an avascular area, </p>
			<p begin="00:07:06.733" end="00:07:35,799" style="1">following which the leucotome and the nasal septum periosteal elevator are introduced. </p>
			<p begin="00:07:35.800" end="00:07:45,866" style="1">A similar opening is then made on the opposite side. </p>
			<p begin="00:07:45.866" end="00:07:50,166" style="1">In the following procedure, the surgeon inserts the leucotome into the brain. </p>
			<p begin="00:07:50.166" end="00:07:55,932" style="1">He is guided by the neurologist in order to keep the brain incision constantly in the plane of the coronal suture. </p>
			<p begin="00:07:55.933" end="00:08:12,399" style="1">His first move is to penetrate directly through the brain from one opening in the skull to the other. </p>
			<p begin="00:08:12.400" end="00:08:31,500" style="1">[The surgeon carefully follows the neurologist so that they can penetrate the skull correctly.] </p>
			<p begin="00:08:31.500" end="00:09:08,000" style="1">His second move is to locate the faults in the midline, always keeping in the plane of the coronal suture. </p>
			<p begin="00:09:08.000" end="00:09:18,433" style="1">The surgeon then clamps a hemostat on the blunt dissector, introduces it into the incision, and cuts to within one centimeter of the midline. </p>
			<p begin="00:09:18.433" end="00:09:25,266" style="1">The surgeon must be careful to avoid the anterior cerebral artery, laceration of which will lead to serious bleeding. </p>
			<p begin="00:09:25.266" end="00:09:30,799" style="1">He must also remain in front of the anterior perforated space with its many penetrating vessels. </p>
			<p begin="00:09:30.800" end="00:09:35,533" style="1">Still guided by the neurologist, the surgeon cuts the upper quadrant in the same way, </p>
			<p begin="00:09:35.533" end="00:09:41,899" style="1">always maintaining the instrument in the plane of the coronal suture, as indicated by the guiding neurologist. </p>
			<p begin="00:09:41.900" end="00:09:45,733" style="1">It seems to be of little importance whether or not the ventricle is entered. </p>
			<p begin="00:09:45.733" end="00:09:50,699" style="1">The incisions are irrigated out with normal saline in order to control hemorrhage. </p>
			<p begin="00:09:50.700" end="00:10:12,700" style="1">Usually there is very little bleeding, most of this coming from the superficial cortical vessels. </p>
			<p begin="00:10:12.700" end="00:10:19,100" style="1">The incisions are now deepened by radial stab incisions, which push the vessels before them, </p>
			<p begin="00:10:19.100" end="00:10:24,466" style="1">preventing further bleeding, and at the same time, interrupting more completely the fibers in the frontal lobe. </p>
			<p begin="00:10:24.466" end="00:10:54,899" style="1">It is when these remaining fibers are being severed that the patient often becomes disoriented. </p>
			<p begin="00:10:54.900" end="00:11:00,933" style="1">The surgeon starts on the second side, inserting the leucotome through the incision, </p>
			<p begin="00:11:00.933" end="00:11:03,899" style="1">where it can be seen coming out on the surface of the brain. </p>
			<p begin="00:11:03.900" end="00:11:21,566" style="1">This shows the delicacy and accuracy of the method. </p>
			<p begin="00:11:21.566" end="00:11:28,399" style="1">When the operation has been completed on both sides, the surgeon injects a few drops of iodized oil </p>
			<p begin="00:11:28.400" end="00:11:54,400" style="1">into the upper and lower extremities of the incision, in order to demonstrate by x-ray their exact location. </p>
			<p begin="00:11:54.400" end="00:12:06,800" style="1">This is of importance, since a failure of the operation can often be correlated with the erroneous placement of the incisions. </p>
			<p begin="00:12:06.800" end="00:12:22,300" style="1">[X-ray displays image of incision] </p>
			<p begin="00:12:22.300" end="00:12:27,400" style="1">[The End]</p>
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