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4. Coca erythroxylon and its derivatives: a résumé of their history, botanical origin, production and cultivation, chemical composition, therapeutic application, physiological action, and medicinal preparations : embracing reports on their employment in general and minor surgery, ophthalmology, otology, laryngology, gynaecology, genito-urinary, nasal, and dental surgery, in the treatment of the alcohol and opium habits, in general medicine, etc etc