1. Establishing effectiveness for drugs intended to treat male hypogonadotropic hypogonadism attributed to nonstructural disorders Publication: Silver Spring, MD : Center for Drug Evaluation and Research, May 2018 Subject(s): Clinical Trials as Topic -- standardsDrug Evaluation -- standardsEndpoint DeterminationHypogonadism -- drug therapyResearch DesignHumansUnited StatesUnited States. Department of Health and Human Services.United States. Food and Drug Administration.