BIOTECHNOLOGY SEMINAR SERIES National Library of Medicine 8600 Rockville Pike Bethesda, Maryland 20894 This administrative document contains cataloging data on videocassettes produced by the National Library of Medicine in the field of biotechnology information. More information about the Library's activities in biotechnol- ogy may be requested from the Chief, National Center for Biotechnology Information Branch, Lister Hill Center, National Library of Medicine, Bethesda, MD 20894. BIOTECHNOLOGY SEMINAR SERIES National Library of Medicine I j n developing and implementing the concept of a National Center for Biotechnology Information, the National Library of Medicine has instituted a forum for the experts to present information about biotechnology and its cognate disciplines. This has resulted in a series of public lectures, held at the Library. By videotaping these talks, the Library has captured a unique survey of the content and future of this burgeoning field. The tapes may be viewed at the NLM or borrowed by other libraries on 3/4-inch videocassettes from the Regional Medical Libraries. 1 BIOTECHNOLOGY SEMINAR SERIES 20 January 1987 Dr. Arthur Nienhuis National Heart Lung Blood Institute Molecular Genetics: An Overview QH430VCNo.l 1987 This introductory talk presents a general description of recent conceptual and methodological advances in the field of molecular genetics. The implications of these advances are considered, in particular as they apply to the diagnosis and understanding of inherited diseases. 26 February 1987 Dr. Helen Donis-Keller Collaborative Research, Inc. Mapping the Human Genome with Genetic Markers QH 445.2 VC No. 11987 Dr. Donis-Keller describes the use of restriction fragment polymorphisms (RFLPs) as genetic markers for assigning the location of individual genes on a chromosome. This approach has been used in the analysis of such human diseases as Huntington's disease, Duchenne muscular dystrophy and cystic fibrosis. The technique is finding applications in the diagnosis of genetic diseases and in forensic medicine. 5 March 1987 Dr. Arthur Nienhuis National Heart Lung Blood Institute Using Recombinant DNA Technology QU 58 VC No. 10 1987 This is a more detailed description of many of the specific methods used in recombinant DNA technology. Dr. Nienhuis addresses the unique power of these methods, both in the analysis of biological phenomena and in the production of useful products. 20 March 1987 Dr. Temple Smith Dana Farber Cancer Institute (Harvard) Syntactic and Systematic Structure in Genetic Sequences QU58VCNo.91987 Dr. Smith considers the "language" elements used by living organisms as they store and transfer genetic information. He then describes newly developed computer methods which attempt to analyze these elements in order to determine structure-function relationships in gene products. 2 BIOTECHNOLOGY SEMINAR SERIES 30 April 1987 Dr. Frederic M. Richards Yale University Proteins: the All-Pnrnose Biological Polymers QU55VCNo.61987 This is an account of recent accelerating progress in understanding the structure and function of proteins. It addresses the computerized manage- ment systems which are needed for gathering, storing, and analyzing this information, which is mainly derived from X-ray crystallography and from nuclear magnetic resonance spectroscopy. 22 May 1987 Dr. David Kingsbury National Science Foundation Information Requirements for Public Policy Decisions Related to Biotechnology W 84.1 VC No. 1 1987 Dr. Kingsbury describes the issues in public policy which are being generated as a result of recent progress in biotechnology, and enumerates the types of information which are needed for the effective resolution of these issues. 5 June 1987 Dr. Daniel Masys National Library of Medicine Biotechnology in the National Library of Medicine:Present and Future Z 699.5.B53 VC No. 1 1987 This presentation outlines the NLM's current and projected activities dealing with the information needs in the field of biotechnology. Dr. Masys particularly addresses the problems posed by the accelerating rate at which data are being generated, and the complexities involved in retrieving these data from diverse information storage systems. 17 September 1987 Dr. Mark Pearson E.I. duPont de Nemours Protein Engineering and Automated Nucleotide Sequencing QU58VC No. 121987 Dr. Pearson describes the construction in the laboratory of a functioning transport protein, and outlines the features of a newly developed automated system for nucleotide sequencing of DNA. 3 BIOTECHNOLOGY SEMINAR SERIES 22 October 1987 Dr. Norman G. Anderson L.S.B. Corporation Indexing the Human Genome QH 445.2 VC No. 2 1987 Newer methodologies for first-level analysis of human gene products are described and evaluated as tools required for indexing the human genome. In particular, he explores the utility of the technique of two dimensional gel electrophoresis, and enumerates the information needs which are inherent in the method. 10 November 1987 Dr. Harold Morowitz Yale University Information Technology and the Structure of Biological Theory QH 303.6 VC No. 1 1987 Dr. Morowitz considers the quantity, quality, and complexity of currently emerging biological insights. He projects a plan for the overall handing and exploiting of this information, and outlines the promise to be derived from such an effort. 27 January 1988 Dr. Douglas Brutlag Stanford University BIQNET: A Network and Computer Resource for Molecular Biology Z699.5B53VCNo.2 1988 The existing and potential capabilities of this large biology oriented communication network are discussed, in the context of the databases it can access and the community it serves. 10 February 1988 Dr. Charles Gasser Monsanto Company Genetic Engineering and Cron Improvement SB 123.57 VC No. 11988 Dr. Gasser provides insights into the current and future impacts of gene modification in the field of agriculture. He recounts experiences in the production of pesticide and insect resistant plants which were developed using recombinant DNA technology. The examples he cites dramatically illustrate the potential of this technology in crop production. 4 ^JtOTECHNOLOGY SEMINAR SERIES 28 March 1988 Dr. Eric Lander Whitehead Institute Human Genome Project: What Do We Hone to I earn? QH 445.2 VC No. 4 1988 This talk outlines the wealth of information which can be directly determined or confidently inferred from genetic mapping of the human and other genomes. Dr. Lander points out the overriding need for understand- ing the function of genes and gene products, rather than just their structure. 28 March 1988 Dr. Charles Cantor Columbia University Human Genome Project: Problems and Prospects QH 445.2 VC No. 3 1988 Dr. Cantor reviews and compares the several types of mapping which must be performed to understand gene structure. He describes preliminary efforts in the physical mapping of human chromosome 21, citing the complexities involved. He tabulates major computing needs in this overall effort. 7 June 1988 Dr. W. French Anderson National Heart Lung & Blood Institute, NTH Prospects for Human Gene Therapy QZ50VCNo.l8 1988 Dr. Anderson reviews the currently most promising means for using gene therapy in managing various disease states. He outlines a technique by which genetically modified cells can be used in a specific cancer chemo- therapy protocol, and describes a new method for introducing functioning, phenotypically unique, somatic cells into animals, using the Gunn rat as a model. 16 September 1988 Dr. Heiner Westphal National Institute of Child Health & Human Development, NIH Transgenic Mammals and Biotechnology QL959VCNo.3 1988 In this talk, Dr. Westphal describes the technique of microinjection of cloned DNA fragments into mouse preimplantation embryos for the 5 BIOTECHNOLOGY SEMINAR SERIES purpose of producing tissue specific gene expression. His studies primarily concern the production of tumors in the mouse ocular lens. He also describes a method for inducing the production of tissue plasminogen activator m milk. 6 Regional Medical Libraries Reg'"" 1 Greater Northeastern Regional Medical Library Program The New York Academy of Medicine 2 East 103rd Street New York, New York 10029 (212) 876-8763 Region 2 Southeastern/Atlantic Regional Medical Library Services University of Maryland Health Sciences Library 111 South Greene Street Baltimore, Maryland 21201 (301) 328-2855 (1-800-638-6093) Region 3 Greater Midwest Regional Medical Library Network University of Illinois at Chicago Library of the Health Sciences P.O. Box 7509 Chicago, Illinois 60680 (312) 996-2464 Region 4 Midcontinental Regional Medical Library Program McGoogan Library of Medicine University of Nebraska Medical Center 42nd and Dewey Avenue Omaha, Nebraska 68105-1065 (402) 559-4326 Region ? South Central Regional Medical Library Program The University of Texas Health Science Center at Dallas 5323 Harry Hines Blvd. Dallas, Texas 75235-9049 (214) 688-2085 Reg'"" 6 Pacific Northwest Regional Health Sciences Library Service Health Sciences Library and Information Center University of Washington Seattle, Washington 98195 (206) 543-8262 Region 7 Pacific Southwest Regional Medical Library Service Louise Darling Biomedical Library University of California 10833 Le Conte Avenue Los Angeles, California 90024-1798 (213) 825-1200 t 7 NOTES 8 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutes of Health January 1989