This presentation provides an overview of pinta using clinical subjects, histologic slides, and scenes from locations in Mexico and the laboratory. Pinta is a chronic disease found in poverty-stricken areas of the tropics. It is characterized by skin lesions of various colors ranging from white, coffee, red, blue, and violet to almost black. These lesions occur only on the exposed surfaces of the body. Produced experimentally, the disease appears to go through three stages: 1) the appearance of a single patch; 2) the spread of lesions to other parts of the body; and 3) a final stage in which flat spots become wildly discolored. Male and female clinical subjects of all ages are presented to illustrate the three stages and to compare and contrast the lesions with those of leprosy, syphilis, ringworm, eczema, and psoriasis. Diagnostic tests used to isolate the Treponema carateum and differentiate it from other spirochetes are described and demonstrated. The diagnostic uses of the Wasserman reaction are discussed in detail. The transmission by direct contact and by insects and flies is explored. The treatment using arsenicals, neoarsenicals and penicillin is discussed briefly.