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Transgenic mammals and biotechnology

Other Title(s):
Biotechnology seminar series
Author(s):
Westphal, Heiner.
National Library of Medicine (U.S.)
Publication Date:
1988
Publisher:
Bethesda, MD. : National Library of Medicine, 1988
Language(s):
English
Format:
Moving image
050 min.
Sound
Color
Subject(s):
Biotechnology
Mammals -- embryology
Mammals -- genetics
Rights:
The National Library of Medicine believes this item to be in the public domain.
Identifier(s):
NLMUID: 8801111A (See catalog record)
Permanent Link:
http://resource.nlm.nih.gov/8801111A
Description:
Dr. Heiner Westphal presents his research on transgenic mice in this part of the Biotechnology Seminar Series. Initially, Dr. Westphal explains how outside genes are introduced into a mouse embryo creating a germ-line that is expressed in every cell of the body. He uses drawings to illustrate how the cells are implanted in the embryo. The purpose of the transplantation is to develop a model whereby a tumor can be developed in a particular part of the body. In the mouse model the cancer is developed in the lens. Dr. Westphal shows how the cancer develops day by day. Mouse models are also used to track the AIDS virus. Both CAT and TAT constructs are used. Dr. Westphal and his team found that megaloviruses can activitate AIDS in people. Further, Dr. Westphal describes how the development of a protein, human TPA, introduced in a mouse's milk can be used as an effective tumor treatment. In the future, he sees the opportunity to use embryonic stem cells as a therapy. The therapy is called homologous gene targeting. Dr. Westphal then took questions from the audience.
Other Title(s):
Biotechnology seminar series
Author(s):
Westphal, Heiner.
National Library of Medicine (U.S.)
Publication Date:
1988
Publisher:
Bethesda, MD. : National Library of Medicine, 1988
Language(s):
English
Format:
Moving image
050 min.
Sound
Color
Subject(s):
Biotechnology
Mammals -- embryology
Mammals -- genetics
Rights:
The National Library of Medicine believes this item to be in the public domain.
Identifier(s):
See catalog record: 8801111A
Permanent Link:
http://resource.nlm.nih.gov/8801111A
Description:
Dr. Heiner Westphal presents his research on transgenic mice in this part of the Biotechnology Seminar Series. Initially, Dr. Westphal explains how outside genes are introduced into a mouse embryo creating a germ-line that is expressed in every cell of the body. He uses drawings to illustrate how the cells are implanted in the embryo. The purpose of the transplantation is to develop a model whereby a tumor can be developed in a particular part of the body. In the mouse model the cancer is developed in the lens. Dr. Westphal shows how the cancer develops day by day. Mouse models are also used to track the AIDS virus. Both CAT and TAT constructs are used. Dr. Westphal and his team found that megaloviruses can activitate AIDS in people. Further, Dr. Westphal describes how the development of a protein, human TPA, introduced in a mouse's milk can be used as an effective tumor treatment. In the future, he sees the opportunity to use embryonic stem cells as a therapy. The therapy is called homologous gene targeting. Dr. Westphal then took questions from the audience.